Scientists Identify Molecule That Cuts Appetite, Lowers Obesity in Mice; Could Help Develop ‘Workout Pill’

Physical exercise offers a wide range of benefits for the human body. Scientists might now be closer to figuring out how to deliver the benefits of exercise in just a single pill. Researchers at Baylor College of Medicine have identified a molecule produced after an intense regimen of physical exercise, which is responsible for reducing both food intake and obesity in mice. Understanding how these physiological processes work could one day help in the development of a medication for people unable to get enough exercise.

“Regular exercise has been proven to help weight loss, regulate appetite and improve the metabolic profile, especially for people who are overweight and obese,” said co-corresponding author Dr. Yong Xu, Professor, Associate Director for Basic Sciences at Baylor College of Medicine. “If we can understand the mechanism by which exercise triggers these benefits, then we are closer to helping many people improve their health,” he added.

“We wanted to understand how exercise works at the molecular level to be able to capture some of its benefits,” said Dr. Jonathan Long, co-author of the study which was published in Nature on June 15.

Citing a potential benefit of the research, he explained, “For example, older or frail people who cannot exercise enough, may one day benefit from taking a medication that can help slow down osteoporosis, heart disease or other conditions.” 

Scientists at the Baylor College of Medicine and Stanford School of Medicine conducted an analysis of blood plasma compounds from mice, following an intense regimen of physical exercise. The researchers identified a modified amino acid called Lac-Phe, which prompted a reduction in food intake by over 50 percent in a 12-hour period. When administered to the mice, Lac-Phe resulted in lowered caloric intake and reduced body weight over a 10-day period.

The scientists will now study how Lac-Phe mediates its effects in the body, including the brain, according to Xu. “Our goal is to learn to modulate this exercise pathway for therapeutic interventions,” he added.


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Fitness Gear

We all need a workout outfit that flatters and feels comfortable—and stays put. Our editors rounded up a number of the simplest workout gear for real women because there’s nothing wrong with eager to look good while breaking a sweat.

Loose, oversized tees paired with baggy pants are pass when it involves exercising or doing yoga. Rather, it’s all about colourful, chic gym clothes that hug your curves and assist you make a method statement.

These snug, compression garments are scientifically engineered and are essential for workouts, yoga, gyms or maybe just an off-the-cuff jog.

Fitness gear is about safety

Talking about the importance of fitness gear, They are extremely important for 2 reasons — performance and safety. These clothes apply a equitqble pressure on different parts of our body. This, in turn, stimulates blood flow and helps our muscles work optimally. It enhances their performance by providing much needed oxygen to specific body parts and muscles that are being worked out. This reduces the development of metabolic wastes and lactic acid.

When you are exercising at a better level, there are chances of things going wrong and your gear can protect you from external temperature changes, and even accidental falls, and injuries. Furthermore, it allows you to perform at your best and the highest level. These special workout gears are made with fabrics that are all-season friendly — they keep you warm in winter and funky in summer.

Anti-bacterial material helps avoid body odour

Fitness gear of reputed brands are made from fabrics that are anti-bacterial, in order that they help minimise body odor .

Spoilt for choice

There are many varieties of fitness gear available. The idea is to find something that you are comfortable in, which will allow you to move to the best of your ability. These tight fit clothes are available during a spread of clothes including vests, racer back tops, long-sleeved tees, hooded jackets, full-length and knee-length tights, calf-guards, skull caps, and ankle and full socks.

Tips to keep in mind while working out

1. Wear the right gym gear to get the best out of your workout — snug compression fits always protect you while you exercise.

2. The right shoes — ones that support you — are important.

3. Spraying on some anti-perspiration products can help minimise excessive odour.

4. Keep yourself hydrated all the time — before, during and after your gym session.

5. Avoid wearing makeup when you are exercising.

6. Use a hair tie or hair band when you are doing yoga and cardio.

7. Avoid fungal infection by keeping yourself clean and dry.

8. Protect your skin with petroleum jelly if you have excessively dry skin.

9. After your gym session make sure you wash the sweat off your face and change into fresh, dry clothes.

Fitness means various things to different people and Health has something for everybody , whether you’re just getting started with a workout routine or are training since before TikTok was a thing.




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