Tag: Morounfolu Olugbosi

Can a Pledge to End TB Stick This Time Around? — Global Issues

In India, a doctor checks a patient’s x-ray for lung damage, which may indicate tuberculosis. Credit: ILO/Vijay Kuty
  • Opinion by Morounfolu Olugbosi (pretoria, south africa)
  • Inter Press Service

  • On May 8, there will be an interactive multistakeholder hearing at the UN as part of the preparatory process toward High-level meeting on the fight against tuberculosis. The event will be broadcast live on UN Web TV.

    Meanwhile, the head of the World Health Organization (WHO), Tedros Adhanom Ghebreyesus, has unveiled plans to speed up the licensing and use of effective novel vaccines against tuberculosis (TB), the second leading infectious killer after COVID-19 and the 13th leading cause of death worldwide. January 2023

PRETORIA, South Africa, May 08 (IPS) – This week, the United Nations will host two days (May 8-9) of preliminary talks to plan a larger conference on tuberculosis (TB) in September. These preliminary talks will be held in New York City, the epicenter of the last significant surge of TB cases in the United States (U.S.) thirty years ago.

TB is a disease that strikes hardest in impoverished places, and the last U.S. outbreak was no different. Disadvantaged urban communities hit hard by the HIV/AIDS pandemic bore the brunt of the outbreak.

Yet, at the outbreak’s peak in 1992, less than 27,000 people in the U.S. were infected with TB. Today, an estimated 304,000 people are infected with TB in South Africa every year, while just under 3,000,000 people are infected with TB in India. The scope of the disease today far exceeds what the U.S. saw three decades ago, much less what it sees now.

TB deaths have risen across the world for two consecutive years; at this point it kills more people than COVID-19. Globally, an estimated 10.6 million people were infected with TB, but only 6.4 million people were diagnosed. The other 4.2 million people infected with this potentially lethal and debilitating disease slipped through the cracks.

In 2018, the UN held the first high-level meeting on TB. More than half of the UN member states sent delegations and 15 heads of state spoke at the event.

In a resolution endorsed by the entire UN General Assembly, every nation pledged to invest, by 2022, a total of US$2 billion annually for TB research and US$13 billion annually for TB diagnostics, treatment and care. Other commitments—to treat more people and prevent more active disease—were also made.

The world got off to a slow start on meeting these pledges and then the pandemic hit. Many of the goals were not reached. We were delighted, for example, that the annual research budget for TB research finally reached US$1 billion in 2021, because it was a critically important achievement—but the actual goal was twice that amount.

And less than half of what was pledged annually on diagnostics, treatment and prevention—US$5.4 billion—was actually provided in 2021.

There are bright spots in the fight against TB, of course. Sub-Saharan Africa is the only region that did not suffer a significant slump in TB detection during the COVID-19 pandemic. But with just under 40% of active TB infections unidentified, it still lags behind much of the world in diagnosing active cases.

Another recent highlight is the approval of new drug-resistant TB treatments that can reduce treatment time from as much as a year and a half (or sometimes even longer) to six months—including one developed by my organization, TB Alliance. African nations like Nigeria and South Africa are taking steps to rolling out this new regimen so that the spread of drug resistant infections can be curbed.

The goal pledged at the 2018 UN meeting was that, between 2018 and 2022, 1.5 million people with drug-resistant TB (DR-TB) would be treated—this is a critical slice of the TB caseload. Yet only 649,000 DR-TB patients were treated between 2018 and 2021.

There is optimism that the number of DR-TB patients who can be treated will escalate, given the new treatments, but funding and resources must increase.

The bottom line is this: TB was the most lethal infectious disease before the COVID-19 pandemic, and as COVID recedes, it is once again the worst. As leaders prepare to meet in New York City and start drafting a new set of promises in the form of the next Political Declaration on TB, we need the world to commit to ending this disease, which has killed too many people for far too long.

But this time around, we also need the world to follow through on its commitments.

Morounfolu (Folu) Olugbosi, M.D. is the Senior Director, Clinical Development at TB Alliance. He works with the clinical development of products in the TB Alliance portfolio and helps to oversee clinical trials in TB endemic countries and heads the South Africa office.

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Progress on Tuberculosis Can Be Achieved in Africa — Global Issues

In Africa only 60% of the estimated TB cases have been diagnosed. All the other infections are hidden by poverty—and so the disease continues to spread. Credit: Jeffrey Moyo/IPS.
  • Opinion by Morounfolu Olugbosi (johannesburg)
  • Inter Press Service

JOHANNESBURG, Nov 08 (IPS) – The news in many parts of the world is that tuberculosis (TB) is reclaiming the title of the world’s most deadly infection, even as the COVID-19 pandemic continues to kill an estimated 1,450 people daily around the world. But this is not news to African countries, which are home to one third of the people globally who die from TB, even though they have less than one fifth of the world’s population.

And on our continent, the real burden might be worse: only 60% of the estimated cases have been diagnosed. All the other infections are hidden by poverty—and so the disease continues to spread.

Consider Zanyiwe’s story, who is recovering from TB a fifth time. Her son-in-law died from the disease, and her 18-month old granddaughter has it currently. TB has hammered her family and her community in Cape Town, South Africa—but this story could be set in Nigeria, Kenya, or just about anywhere, as TB has never been contained in Africa.

Four years ago, there was hope that TB might be receiving the attention it deserves. The United Nations held a High-Level Meeting with heads of state in September 2018 where more than half of the world’s nations convened to rally support to tackle TB. Many pledges were made; fulfillment of these pledges got off to a slow start and then the COVID-19 pandemic derailed things completely.

The first commitment was to find and treat 40 million people with TB between 2018 and 2022, including 3.5 million children and 1.5 million people with drug-resistant TB. We’re 19% behind that overall goal, but 32% behind with children and 46% behind with drug-resistant TB. We now have new and shorter treatment regimens for TB and drug-resistant TB; using these new technologies could make next year, when another UN high level meeting on TB will convene, a different story.

The second commitment was to provide preventive treatment for 30 million people at risk for TB infections. We’re 48% behind here; while we already exceeded the sub-target of reaching 6 million people with HIV with preventive treatment, from 2018-2021 we’ve only provided preventive treatment to 2.2 million household contacts of people with TB, 11.5% of the goal. Once again, we now have new, more effective and shorter preventive regimens to deploy—but we need the outreach capacity and willingness of countries to get the treatment into the hands of the people who need it.

The third and fourth commitments are about funding. Leaders pledged to spend a total of US$13 billion annually on prevention, diagnosis and treatment by 2022; in 2021 only 42% of that yearly goal was spent. For TB research, US$2 billion annually was pledged by 2022 but in 2021 research spending reached less than half that amount (46%). Rolling out the new treatments and developing even better ones will require a stronger embrace of these commitments; the status quo simply will not get us there.

While we have yet to finish 2022, it is obvious that we will not meet these goals. With that being said, there have been signs of progress worth drawing attention to.

First, Gabon, Kenya, Liberia, Namibia, Republic of Congo, Sierra Leone, and Uganda all made progress in finding more cases of TB last year. And Central African Republic, Democratic Republic of Congo, Mozambique, Nigeria, Tanzania, and Zambia have all made progress throughout the pandemic—showing the political will needed to keep their people healthier. Overall, Africa found 4% more TB in 2021 than in 2020. It’s a start—and we can do better.

New TB medicines are being supported by the World Health Organization (WHO). Six-month therapy for drug-resistant TB has been approved in more than 20 countries, including the Democratic Republic of Congo, Mozambique, South Africa, and Zimbabwe. And Ethiopia, Ghana, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe are working to roll out a new TB prevention treatment.

In Africa, we will not mistake these initial signs of progress for anything more significant. Yet, at the same time, it is still progress to be respected and built upon. Next year, the world will consider their long-ignored pledges. We need to show the world that it is time to move forward; all that’s been missing is the same thing that’s been missing for far too many years: political will.

Morounfolu (Folu) Olugbosi, M.D. is the Senior Director, Clinical Development, TB Alliance. He works with the clinical development of products in the TB Alliance portfolio and helps to oversee clinical trials in TB endemic countries and heads the South Africa office.

© Inter Press Service (2022) — All Rights ReservedOriginal source: Inter Press Service

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