NFL Week 15 upset picks (Dolphins sweep Bills, Colt McCoy beats Broncos in top predictions)

Betting on underdogs on the moneyline this season hasn’t been profitable if you took every underdog to win every week, but that’s why the BetSided team is here to give you the BEST underdog picks in the NFL.

This season, the BetSided team has gone 30-35 (+12.16 units) with our upset picks, and we’re looking to add to a 2-1 performance from Week 14.

There are FIVE underdogs that you could consider in this week’s slate. Let’s dive into the picks:

Best NFL Upset Picks for Week 15 of 2022 Season

Arizona Cardinals (+125) at Denver Broncos

I implore you to trust Colt McCoy. Sure, he’s no Kyler Murray, but I trust him in this matchup. So far this season, in relief of Murray, McCoy has completed 69.4 percent of passes for a rating of 81.7.

Those aren’t eye-popping numbers, but I think they’re good enough to lead the Arizona Cardinals past the Denver Broncos.

Especially considering Arizona may be facing Brett Rypien if Russell Wilson is ruled out.

Rypien has completed only 57.3 percent of his passes in his career, throwing for three touchdowns and six interceptions. If Wilson can’t go, the terrible Denver offense is going to be even worse.

If that’s the case, Arizona may only need to score twice to get past Denver.

So, let me be the first to tell you, if you’re going to bet on this game on Sunday, let’s trust McCoy to do enough to get the job done. – Iain MacMillan

Tennessee Titans (+130) at Los Angeles Chargers

The Tennessee Titans are coming off a terrible loss to the Jacksonville Jaguars in Week 14, but they have an ideal bounce-back spot, at least for their offense, this week.

Tennessee takes on the Los Angeles Chargers, who have the worst run defense in the NFL this season, allowing 5.4 yards per carry.

Derrick Henry should go crazy for Tennessee, and the team has shown that Henry is the end all be all on offense this season.

After back-to-back losses, this seems like a spot to buy low on the Titans against the Chargers team that is one of the worst in the NFL in net yards per play. – Peter Dewey

Pittsburgh Steelers (+125) at Carolina Panthers

This line is an inflated overreaction to both Mitchell Trubisky likely getting the start for Pittsburgh this weekend in Carolina, along with the Panthers’ upset of the Seattle Seahawks in Seattle in Week 14.

Have the Panthers looked better under interim head coach Steve Wilks? Absolutely. In fact, Carolina’s defense over the last month or so has been playing at a near-elite level.

At the same time, despite Sam Darnold’s strong recent play, the Steelers’ pass rush with T.J. Watt back in the mix could see the former No. 3 pick in the draft revert back to his turnover-prone days.

Pittsburgh is tied for second in the NFL with 14 interceptions. Last week, the Baltimore Ravens ran it constantly, not allowing the Steelers’ pash rush to be effective. Carolina runs often, but nowhere near the same level.

These are the spots Mike Tomlin has typically thrived in his career. Since his head coaching career in Pittsburgh began, he’s 49-30-5 ATS as a dog, going 40-44-0 straight up.

Trubisky with a full week of reps can still be serviceable in this spot, and I like the Steelers’ defense in particular to get back on track this week. Give me Pittsburgh on the road in this week’s upset special. – Ben Heisler

Miami Dolphins (+260) at Buffalo Bills

The Miami Dolphins did it once and they can do it again.

They can – and will – beat the Buffalo Bills this week. Buffalo hasn’t looked amazing over the last month.

The Bills escaped against the Lions, faced a subpar Patriots team and was in another dogfight with the New York Jets last week.

The Dolphins have the most speed at the receiver position in the league and will be able to put pressure on the Bills secondary. Also, without Von Miller, Buffalo’s pass rush is compromised. If Tua Tagovailoa can be 50% better than his awful showing last week, the Dolphins can get this win. – Donnavan Smoot

Detroit Lions (-108) at New York Jets

I’m drinking all of the Detroit Lions’ Kool-Aid and think they’ve got a great chance to make the playoffs. This offense is legit, ranking seventh in yards per play (5.9), while the New York Jets are a lowly 20th (5.3).

Yes, New York’s defense is among the NFL’s best. That being said, Detroit’s unit is quickly improving and I have serious questions about the Jets’ offense. Mike White likely won’t be fully healthy, and I’m not sure New York can keep up.

The Lions have covered the spread in four straight games as underdogs, including winning three of those outright. I expect Detroit’s spectacular rise to continue as Jared Goff and Co. pick up the upset win. – Joe Summers