Matthew Perry’s ex says he vowed never to inject drugs before fatal ketamine shot

Matthew Perry’s ex and former assistant claims the late “Friends” star vowed never to use intravenous drugs because of how terrified of needles he was.

A federal investigation into Perry’s death, however, revealed he had been injected with ketamine at least 21 times during the last week of his life.

“This is the weird thing to me … Matthew always, always told me that he would never, ever, use needles or inject anything into his body,” Kayti Edwards told The Mirror in an interview published Friday.

“He didn’t even want to have tattoos.”

Edwards admitted that she would “often see [Perry] very high and using lots of different drugs,” which “scared” her because she warned him that mixing substances would kill him.

“But he was like, ‘You only die when you use needles … and I would never, ever, ever do that,’” she recalled.

Edwards dated the “Whole Nine Yards” star in 2006 and then worked for him as an assistant in 2011. She said they remained friends up until his death last October at age 54.

Authorities arrested and charged five people, including two doctors and his assistant, for their roles in Perry’s death from ketamine.

Officials said Perry’s then-assistant, Kenneth “Kenny” Iwamasa, administered the final dose of ketamine that would cause the actor to pass out and drown in his hot tub. Iwamasa, 59, went on to discover Perry floating face down in the water.

Iwamasa pleaded guilty on Aug. 7 to one count of conspiracy to distribute ketamine causing death and faces 15 years in prison when sentenced in his federal case.

Doctors Salvador Plasencia and Mark Chavez were also arrested and charged alongside “Ketamine Queen” Jasveen Sangha and alleged street dealer Erik Fleming.

Law enforcement obtained a text from Plasencia, an urgent care physician in Calabasas, Calif., that showed his and Chavez’s motives and complete disregard for the “17 Again” star’s life.

He once wrote, “I wonder how much this moron will pay” and “Lets [sic] find out.”

Perry had 3.54 micrograms per milliliter of ketamine in his bloodstream at the time of his death, which is equivalent to the amount used in general anesthesia.

A medical expert previously told Page Six that ketamine is “generally safe when administered by trained health professionals in a medical setting for the treatment of depression or post traumatic stress disorder.”

The “Fools Rush In” actor had been going for professional ketamine infusions; however, his last official visit had taken place more than a week before his death.